HuagongsheHuagongshe Chemistry Print Report · For research reference only
[2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(2-methyl-5-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-[1,2,3]triazol-4-yl}-phenyl)-methanone → HCID 11541444, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(2-methyl-5-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-[1,2,3]triazol-4-yl}-phenyl)-methanone | HCID 11706669 | — |
| Reactant | 2-(2-Azidoethoxy)oxane | HCID 60074287 | — |
| Reactant | [2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(5-ethynyl-2-methoxy-phenyl)-methanone | HCID 86605526 | — |
| Product | HCID 11541444 | HCID 11541444 | — |
Reaction Steps
The reaction was carried out similarly as described in the preparation of compound 101, using compound 427 (0.42 mmol) and compound 408 (0.42 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 20:80 to 60:40 as the eluent to afford the title compound as light orange foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293772B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-9bea2da4d0cc488b9b3115b887389233 |
| Source note | uspto-grants-2012_10 |