HuagongsheHuagongshe Chemistry Print Report · For research reference only
(5-Amino-2-methyl-phenyl)-[2-chloro-4-(2,4-difluoro-phenylamino)-phenyl]-methanone → (5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-fluoro-phenylamino)-phenyl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (5-Amino-2-methyl-phenyl)-[2-chloro-4-(2,4-difluoro-phenylamino)-phenyl]-methanone | HCID 11538012 | — |
| Reactant | [2-Chloro-4-(4-fluoro-phenylamino)-phenyl]-(2-methyl-5-nitro-phenyl)-methanone | HCID 68419037 | — |
| Product | (5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-fluoro-phenylamino)-phenyl]-methanone | HCID 68418042 | — |
Reaction Steps
The reaction was carried out similarly as described in the preparation of compound 404, using compound 428 (19.2 mmol). The crude product was purified by flash chromatography using EtOAc/petroleum ether (40-60) 1:2 followed by 2:3 as the eluent to afford the title compound as solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293772B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-f350e1b21b7e498e9ba4caefc5eb7af2 |
| Source note | uspto-grants-2012_10 |