HCID 58677657, compound → HCID 86605527, compound

HRID 2067227Notes

Reaction equation

HRID 2067227 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2F)[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]#[CH:26])[CH:22]=[CH:21][C:20]=1[CH3:27])=[O:18].ClC1C=C(NC2C=CC(F)=CC=2)C=CC=1C(C1C=C(C#C[Si](C)(C)C)C=CC=1C)=O>>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:10]=[CH:11][C:12]([F:15])=[CH:13][CH:14]=2)[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]#[CH:26])[CH:22]=[CH:21][C:20]=1[CH3:27])=[O:18]

Participants

3

Reactant 2

HCID 58677657HCID 58677657, compoundHCID 68418431HCID 68418431, compound

Product 1

HCID 86605527HCID 86605527, compound

Procedure

The reaction was carried out similarly as described in the preparation of compound 407, using compound 431 (5.95 mmol). The crude product was used without any further purification.

Workup

  1. customThe crude product was used without any further purification

Sources & evidence

ORD record
ord-fea1a6f66d14459691db3aab90976d3c
Source dataset
uspto-grants-2012_10
Patent number
US08293772B2

Reaction notes

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