Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2067228Generated: November 1, 2026

[2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(2-methyl-5-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-[1,2,3]triazol-4-yl}-phenyl)-methanone → HCID 11577394, compound

https://huagongshe.com/reaction/2067228

Reaction equation

Participants

RoleNameHCIDCharge
Reactant[2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(2-methyl-5-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-[1,2,3]triazol-4-yl}-phenyl)-methanoneHCID 11706669—
Reactant2-(2-Azidoethoxy)oxaneHCID 60074287—
ReactantHCID 86605527HCID 86605527—
ProductHCID 11577394HCID 11577394—

Reaction Steps

The reaction was carried out similarly as described in the preparation of compound 101, using compound 432 (2.06 mmol) and compound 408 (2.06 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 50:50 to 50:50 as the eluent to afford the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08293772B2
Source datasetuspto-grants-2012_10
ORD IDord-b5925b0ecdc84490b065c6674422a3a9
Source noteuspto-grants-2012_10