HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Azidomethyl)-2,2-dimethyl-1,3-dioxolane → HCID 11685044, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Azidomethyl)-2,2-dimethyl-1,3-dioxolane | HCID 11535602 | — |
| Reactant | [2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(2-methyl-5-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-[1,2,3]triazol-4-yl}-phenyl)-methanone | HCID 11706669 | — |
| Reactant | HCID 86605527 | HCID 86605527 | — |
| Product | HCID 11685044 | HCID 11685044 | — |
Reaction Steps
The reaction was carried out similarly as described in the preparation of compound 101, using compound 432 (2.75 mmol) and compound 410 (2.75 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 20:80 to 65:35 as the eluent to afford the title compound as foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293772B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-892c0de2bbf949ca978c97113cdcaf4e |
| Source note | uspto-grants-2012_10 |