HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-azido-acetamide → HCID 11503631, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-azido-acetamide | HCID 3246223 | — |
| Reactant | [2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(2-methyl-5-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-[1,2,3]triazol-4-yl}-phenyl)-methanone | HCID 11706669 | — |
| Reactant | HCID 86605527 | HCID 86605527 | — |
| Product | HCID 11503631 | HCID 11503631 | — |
Reaction Steps
The reaction was carried out similarly as described in the preparation of compound 101, using compound 432 (1.04 mmol) and compound 411 (1.5 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/DCM/petroleum ether (40-60) 0:80:20, 0:100:0 and 10:90:0 as the eluent to afford the title compound as yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293772B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-6e73cc177c5242588fcc582828031066 |
| Source note | uspto-grants-2012_10 |