反应详情

The reaction was carried out similarly as described in the preparation of compound 101, using compound 433 (1.10 mmol) and 3-butyne-1-ol (1.10 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 50:50 to 100:0 as the eluent to afford the title compound as foam.

1. customThe crude product was purified by continuous gradient flash chromatography