反应详情

The reaction was carried out similarly as described in the preparation of compound 116, using compound 434 (0.125 mmol) and 1,1-dimethyl-prop-2-ynylamine (0.125 mmol). The crude product was purified by continuous gradient flash chromatography using MeOH/DCM 0:100 to 5:95 as the eluent to afford the title compound.

1. customThe crude product was purified by continuous gradient flash chromatography