2-Penten-4-yn-1-ol → [2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-{5-[4-(3-hydroxy-propenyl)-[1,2,3]triazol-1-yl]-2-methyl-phenyl}-methanone

Participants

Reaction Steps

The reaction was carried out similarly as described in the preparation of compound 116, using compound 434 (0.15 mmol) and pent-2-en-4-yn-1-ol (0.30 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 30:70 to 50:50 as the eluent to afford the title compound as yellow solid.

Provenance & Evidence