HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Prop-2-yn-1-yl)urea → (1-{3-[2-Chloro-4-(2,4-difluoro-phenylamino)-benzoyl]-4-methyl-phenyl}-1H-[1,2,3]triazol-4-ylmethyl)-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Prop-2-yn-1-yl)urea | HCID 2777182 | — |
| Reactant | (5-Azido-2-methyl-phenyl)-[2-chloro-4-(2,4-difluoro-phenylamino)-phenyl]-methanone | HCID 86605529 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (1-{3-[2-Chloro-4-(2,4-difluoro-phenylamino)-benzoyl]-4-methyl-phenyl}-1H-[1,2,3]triazol-4-ylmethyl)-urea | HCID 11504214 | — |
Reaction Steps
The reaction was carried out similarly as described in the preparation of compound 116, using compound 434 (0.15 mmol) and prop-2-ynyl-urea (0.30 mmol). The crude product was purified by flash chromatography using EtOAc as the eluent to afford a solid. Trituration in MeOH gave the title compound as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293772B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-c3ccf775c6294864b9d297bea68b17a1 |
| Source note | uspto-grants-2012_10 |