HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → [2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(2-methyl-5-{4-[2-(4-methyl-piperazin-1-yl)-ethyl]-[1,2,3]triazol-1-yl}-phenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | [2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-{2-methyl-5-[4-(2-morpholin-4-yl-ethyl)-[1,2,3]triazol-1-yl]-phenyl}-methanone | HCID 11692340 | — |
| Reactant | Toluene-4-sulfonic acid 2-(1-{3-[2-chloro-4-(2,4-difluoro-phenylamino)-benzoyl]-4-methyl-phenyl}-1H-[1,2,3]triazol-4-yl)-ethyl ester | HCID 86605530 | — |
| Product | [2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(2-methyl-5-{4-[2-(4-methyl-piperazin-1-yl)-ethyl]-[1,2,3]triazol-1-yl}-phenyl)-methanone | HCID 11692468 | — |
Reaction Steps
The reaction was carried out similarly as described in the preparation of compound 138, using compound 435 (0.24 mmol) and 1-methyl-piperazine (0.5 mL). The crude product was purified by continuous gradient flash chromatography using MeOH/DCM 0:100 to 15:85 as the eluent to afford the title compound as yellow foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293772B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-477198b81035417b92ae80adfb0688a1 |
| Source note | uspto-grants-2012_10 |