HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethylamine → [2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-{5-[4-(2-diethylamino-ethyl)-[1,2,3]triazol-1-yl]-2-methyl-phenyl}-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | [2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-{2-methyl-5-[4-(2-morpholin-4-yl-ethyl)-[1,2,3]triazol-1-yl]-phenyl}-methanone | HCID 11692340 | — |
| Reactant | Toluene-4-sulfonic acid 2-(1-{3-[2-chloro-4-(2,4-difluoro-phenylamino)-benzoyl]-4-methyl-phenyl}-1H-[1,2,3]triazol-4-yl)-ethyl ester | HCID 86605530 | — |
| Product | [2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-{5-[4-(2-diethylamino-ethyl)-[1,2,3]triazol-1-yl]-2-methyl-phenyl}-methanone | HCID 11692166 | — |
Reaction Steps
The reaction was carried out similarly as described in the preparation of compound 138, using compound 435 (0.24 mmol) and diethylamine (0.5 mL). The crude product was purified by continuous gradient flash chromatography using MeOH/DCM 0:100 to 15:85 as the eluent to afford the title compound as yellow foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293772B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-7969f0d366f246c4b0008aae4a943f06 |
| Source note | uspto-grants-2012_10 |