HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-2-methylaniline → [2-Chloro-4-(4-fluoro-2-methyl-phenylamino)-phenyl]-(2-methyl-5-nitro-phenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-2-methylaniline | HCID 67982 | — |
| Reactant | (4-Bromo-2-chloro-phenyl)-(2-methyl-5-nitro-phenyl)-methanone | HCID 11494123 | — |
| Reactant | [2-Chloro-4-(4-trifluoromethyl-phenylamino)-phenyl]-(2-methyl-5-nitro-phenyl)-methanone | HCID 68419760 | — |
| Product | [2-Chloro-4-(4-fluoro-2-methyl-phenylamino)-phenyl]-(2-methyl-5-nitro-phenyl)-methanone | HCID 68419909 | — |
Reaction Steps
The reaction was carried out similarly as described in the preparation of compound 414, using compound 402 (0.56 mmol) and 4-fluoro-2-methyl-phenylamine (0.56 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 0:100 to 25:75 as the eluent to afford the title compound as yellow foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293772B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-4e6f3c2b6b2d4f87961d41901f27c1bc |
| Source note | uspto-grants-2012_10 |