[2-Chloro-4-(2-methoxy-phenylamino)-phenyl]-(2-methyl-5-nitro-phenyl)-methanone → (5-Amino-2-methyl-phenyl)-[2-chloro-4-(2-methoxy-phenylamino)-phenyl]-methanone

HRID 2067254Notes

Reaction equation

HRID 2067254 reaction equation
NC1C=CC(C)=C(C(C2C=CC(NC3C=CC(C(F)(F)F)=CC=3)=CC=2Cl)=O)C=1.[Cl:29][C:30]1[CH:35]=[C:34]([NH:36][C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=2[O:43][CH3:44])[CH:33]=[CH:32][C:31]=1[C:45]([C:47]1[CH:52]=[C:51]([N+:53]([O-])=O)[CH:50]=[CH:49][C:48]=1[CH3:56])=[O:46]>>[NH2:53][C:51]1[CH:50]=[CH:49][C:48]([CH3:56])=[C:47]([C:45]([C:31]2[CH:32]=[CH:33][C:34]([NH:36][C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=3[O:43][CH3:44])=[CH:35][C:30]=2[Cl:29])=[O:46])[CH:52]=1

Participants

3

Reactant 2

HCID 68417358[2-Chloro-4-(2-methoxy-phenylamino)-phenyl]-(2-methyl-5-nitro-phenyl)-methanoneHCID 68419668(5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-trifluoromethyl-phenylamino)-phenyl]-methanone

Product 1

HCID 68418988(5-Amino-2-methyl-phenyl)-[2-chloro-4-(2-methoxy-phenylamino)-phenyl]-methanone

Procedure

The reaction was carried out similarly as described in the preparation of compound 415, using compound 440 (0.28 mmol). The crude product was used without any further purification.

Workup

  1. customThe crude product was used without any further purification

Sources & evidence

ORD record
ord-7bc2c0c8a3e24ec9b1095039f1789baa
Source dataset
uspto-grants-2012_10
Patent number
US08293772B2

Reaction notes

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