反应详情

The reaction was carried out similarly as described in the preparation of compound 116, using compound 445 (0.03 mmol) and but-3-yn-1-ol (0.06 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 30:70 to 100:0 as the eluent to afford the title compound. 13C NMR (CDCl3) δ 194.7, 149.5, 146.2, 141.1, 138.2, 136.4, 135.7, 134.7, 134.1, 132.6, 131.2, 130.8, 127.4, 127.2, 125.6, 122.1, 120.7, 120.1, 115.8, 112.4, 61.5, 28.6, 19.9, 17.9

1. customThe crude product was purified by continuous gradient flash chromatography