HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Butyn-1-OL → [2-Chloro-4-(4-methoxy-phenylamino)-phenyl]-{5-[4-(2-hydroxy-ethyl)-[1,2,3]triazol-1-yl]-2-methyl-phenyl}-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Butyn-1-OL | HCID 13566 | — |
| Reactant | (5-Azido-2-methyl-phenyl)-[2-chloro-4-(4-methoxy-phenylamino)-phenyl]-methanone | HCID 86605534 | — |
| Product | [2-Chloro-4-(4-methoxy-phenylamino)-phenyl]-{5-[4-(2-hydroxy-ethyl)-[1,2,3]triazol-1-yl]-2-methyl-phenyl}-methanone | HCID 11712360 | — |
Reaction Steps
The reaction was carried out similarly as described in the preparation of compound 116, using compound 448 (0.03 mmol) and but-3-yn-1-ol (0.06 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 30:70 to 100:0 as the eluent to afford the title compound. 13C NMR (CDCl3) δ 194.7, 157.3, 150.5, 146.2, 141.4, 138.1, 135.8, 134.6, 134.2, 132.5, 132.2, 126.5, 125.3, 122.1, 120.6, 120.1, 115.2, 115.0, 111.8, 61.5, 55.6, 28.6, 19.9
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293772B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-ee5abcb455bd4837b1c019d7d5798766 |
| Source note | uspto-grants-2012_10 |