3-(Trifluoromethyl)aniline → HCID 11496666, compound

Participants

Reaction Steps

The reaction was carried out similarly as described in the preparation of compound 148, using compound 452 (0.13 mmol) and 3-trifluoromethyl-phenylamine (0.13 mmol). The crude product was purified by continuous gradient flash chromatography using MeOH/DCM/petroleum ether (40-60) 0:50:50, 0:100:0 and 5:95:0 as the eluent to afford the title compound as yellow solid. 13C NMR (DMSO-d6) δ 196.5, 146.8, 145.7, 142.3, 142.2, 142.1, 135.3, 135.1, 134.4, 132.2, 130.6, 130.2 (q), 127.6, 124.1 (q), 122.0, 120.7, 120.5, 118.5, 117.7 (q), 114.9 (q), 112.0, 60.2, 29.2, 21.9, 18.9

Provenance & Evidence