2,4-Difluoroaniline → HCID 11547651, compound

Participants

Reaction Steps

The reaction was carried out similarly as described in the preparation of compound 148, using compound 456 (0.91 mmol) and 2,4-difluoro-phenylamine (0.91 mmol). The crude product was purified by continuous gradient flash chromatography using MeOH/DCM 0:100, 10:90 as the eluent to afford the title compound as yellow solid. 13C NMR (CDCl3) δ 191.1, 159.6 (dd), 155.9 (dd), 149.1, 146.7, 141.1, 136.1, 135.7, 134.5, 131.7, 131.6, 126.9, 125.1 (dd), 123.8 (dd), 122.8, 121.0, 119.9, 116.1, 112.8, 111.7 (dd), 105.1 (dd), 61.5, 28.7

Provenance & Evidence