HuagongsheHuagongshe Chemistry Print Report · For research reference only
[2-Chloro-4-(3-fluoro-phenylamino)-phenyl]-(2-methyl-5-nitro-phenyl)-methanone → (5-Amino-2-methyl-phenyl)-[2-chloro-4-(3-fluoro-phenylamino)-phenyl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [2-Chloro-4-(3-fluoro-phenylamino)-phenyl]-(2-methyl-5-nitro-phenyl)-methanone | HCID 68417015 | — |
| Reactant | (5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-trifluoromethyl-phenylamino)-phenyl]-methanone | HCID 68419668 | — |
| Product | (5-Amino-2-methyl-phenyl)-[2-chloro-4-(3-fluoro-phenylamino)-phenyl]-methanone | HCID 68416513 | — |
Reaction Steps
The reaction was carried out similarly as described in the preparation of compound 415, using compound 457 (2.25 mmol). The crude product was purified by flash chromatography using EtOAc/petroleum ether (40-60) 1:2 as the eluent to afford the title compound as yellow foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293772B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-4d99f93a5dd54615ab025cdd588786af |
| Source note | uspto-grants-2012_10 |