[2-Chloro-4-(3-chloro-phenylamino)-phenyl]-(2-methyl-5-nitro-phenyl)-methanone → (5-Amino-2-methyl-phenyl)-[2-chloro-4-(3-chloro-phenylamino)-phenyl]-methanone

HRID 2067285Notes

Reaction equation

HRID 2067285 reaction equation
NC1C=CC(C)=C(C(C2C=CC(NC3C=CC(C(F)(F)F)=CC=3)=CC=2Cl)=O)C=1.[Cl:29][C:30]1[CH:35]=[C:34]([NH:36][C:37]2[CH:42]=[CH:41][CH:40]=[C:39]([Cl:43])[CH:38]=2)[CH:33]=[CH:32][C:31]=1[C:44]([C:46]1[CH:51]=[C:50]([N+:52]([O-])=O)[CH:49]=[CH:48][C:47]=1[CH3:55])=[O:45]>>[NH2:52][C:50]1[CH:49]=[CH:48][C:47]([CH3:55])=[C:46]([C:44]([C:31]2[CH:32]=[CH:33][C:34]([NH:36][C:37]3[CH:42]=[CH:41][CH:40]=[C:39]([Cl:43])[CH:38]=3)=[CH:35][C:30]=2[Cl:29])=[O:45])[CH:51]=1

Participants

3

Reactant 2

HCID 68417397[2-Chloro-4-(3-chloro-phenylamino)-phenyl]-(2-methyl-5-nitro-phenyl)-methanoneHCID 68419668(5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-trifluoromethyl-phenylamino)-phenyl]-methanone

Product 1

HCID 68418319(5-Amino-2-methyl-phenyl)-[2-chloro-4-(3-chloro-phenylamino)-phenyl]-methanone

Procedure

The reaction was carried out similarly as described in the preparation of compound 415, using compound 460 (2.13 mmol). The crude product was purified by flash chromatography using EtOAc/petroleum ether (40-60) 1:2 as the eluent to afford the title compound as yellow foam.

Workup

  1. customThe crude product was purified by flash chromatography

Sources & evidence

ORD record
ord-8a57eac49b80444384ad87a5ef598a3e
Source dataset
uspto-grants-2012_10
Patent number
US08293772B2

Reaction notes

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