(5-Amino-2-methyl-phenyl)-[2-chloro-4-(3-chloro-phenylamino)-phenyl]-methanone → (5-Azido-2-methyl-phenyl)-[2-chloro-4-(3-chloro-phenylamino)-phenyl]-methanone

HRID 2067286Notes

Reaction equation

HRID 2067286 reaction equation
[N:1]([C:4]1[CH:5]=[CH:6][C:7]([CH3:30])=[C:8]([C:10]([C:12]2[CH:17]=[CH:16][C:15]([NH:18][C:19]3[CH:24]=[CH:23][C:22](C(F)(F)F)=[CH:21][CH:20]=3)=[CH:14][C:13]=2[Cl:29])=[O:11])[CH:9]=1)=[N+:2]=[N-:3].NC1C=CC(C)=C(C(C2C=CC(NC3C=CC=C([Cl:53])C=3)=CC=2Cl)=O)C=1>>[N:1]([C:4]1[CH:5]=[CH:6][C:7]([CH3:30])=[C:8]([C:10]([C:12]2[CH:17]=[CH:16][C:15]([NH:18][C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([Cl:53])[CH:20]=3)=[CH:14][C:13]=2[Cl:29])=[O:11])[CH:9]=1)=[N+:2]=[N-:3]

Participants

3

Reactant 2

HCID 68418319(5-Amino-2-methyl-phenyl)-[2-chloro-4-(3-chloro-phenylamino)-phenyl]-methanoneHCID 86605524(5-Azido-2-methyl-phenyl)-[2-chloro-4-(4-trifluoromethyl-phenylamino)-phenyl]-methanone

Product 1

HCID 86605539(5-Azido-2-methyl-phenyl)-[2-chloro-4-(3-chloro-phenylamino)-phenyl]-methanone

Procedure

The reaction was carried out similarly as described in the preparation of compound 416, using compound 461 (1.40 mmol). The crude product was purified by flash chromatography using EtOAc/petroleum ether (40-60) 1:6 as the eluent to afford the title compound as yellow syrup.

Workup

  1. customThe crude product was purified by flash chromatography

Sources & evidence

ORD record
ord-919aaa62799b43538fb79769cab8fc28
Source dataset
uspto-grants-2012_10
Patent number
US08293772B2

Reaction notes

Loading…