HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Chloro-4-m-tolylamino-phenyl)-(2-methyl-5-nitro-phenyl)-methanone → (5-Amino-2-methyl-phenyl)-(2-chloro-4-m-tolylamino-phenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Chloro-4-m-tolylamino-phenyl)-(2-methyl-5-nitro-phenyl)-methanone | HCID 68418950 | — |
| Reactant | (5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-trifluoromethyl-phenylamino)-phenyl]-methanone | HCID 68419668 | — |
| Product | (5-Amino-2-methyl-phenyl)-(2-chloro-4-m-tolylamino-phenyl)-methanone | HCID 68420133 | — |
Reaction Steps
The reaction was carried out similarly as described in the preparation of compound 415, using compound 463 (1.78 mmol). The crude product was purified by flash chromatography using EtOAc/petroleum ether (40-60) 1:2 as the eluent to afford the title compound as yellow syrup.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293772B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-6dd06abb9a2d45fbaa22378b7cf8a6a4 |
| Source note | uspto-grants-2012_10 |