HuagongsheHuagongshe Chemistry Print Report · For research reference only
(5-Amino-2-methyl-phenyl)-(2-chloro-4-m-tolylamino-phenyl)-methanone → (5-Azido-2-methyl-phenyl)-(2-chloro-4-m-tolylamino-phenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (5-Amino-2-methyl-phenyl)-(2-chloro-4-m-tolylamino-phenyl)-methanone | HCID 68420133 | — |
| Reactant | (5-Azido-2-methyl-phenyl)-[2-chloro-4-(4-trifluoromethyl-phenylamino)-phenyl]-methanone | HCID 86605524 | — |
| Product | (5-Azido-2-methyl-phenyl)-(2-chloro-4-m-tolylamino-phenyl)-methanone | HCID 86605540 | — |
Reaction Steps
The reaction was carried out similarly as described in the preparation of compound 416, using compound 464 (1.17 mmol). The crude product was purified by flash chromatography using EtOAc/petroleum ether (40-60) 1:9 and 1:6 as the eluent to afford the title compound as yellow syrup.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293772B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-31900f3274fb442fb73a6f7ea686f3ec |
| Source note | uspto-grants-2012_10 |