(5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-trifluoromethyl-phenylamino)-phenyl]-methanone → HCID 68420710, compound

HRID 2067293Notes

Reaction equation

HRID 2067293 reaction equation
NC1C=CC(C)=C(C(C2C=CC(NC3C=CC(C(F)(F)F)=CC=3)=CC=2Cl)=O)C=1.[Cl:29][C:30]1[CH:35]=[C:34]([NH:36][C:37]2[CH:42]=[CH:41][CH:40]=[C:39]([O:43][CH3:44])[CH:38]=2)[CH:33]=[CH:32][C:31]=1[C:45]([C:47]1[CH:52]=[C:51]([N+:53]([O-])=O)[CH:50]=[CH:49][C:48]=1[CH3:56])=[O:46]>>[NH2:53][C:51]1[CH:50]=[CH:49][C:48]([CH3:56])=[C:47]([C:45]([C:31]2[CH:32]=[CH:33][C:34]([NH:36][C:37]3[CH:42]=[CH:41][CH:40]=[C:39]([O:43][CH3:44])[CH:38]=3)=[CH:35][C:30]=2[Cl:29])=[O:46])[CH:52]=1

Participants

3

Reactant 2

HCID 68419668(5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-trifluoromethyl-phenylamino)-phenyl]-methanoneHCID 68420666HCID 68420666, compound

Product 1

HCID 68420710HCID 68420710, compound

Procedure

The reaction was carried out similarly as described in the preparation of compound 415, using compound 466 (2.32 mmol). The crude product was purified by flash chromatography using EtOAc/petroleum ether (40-60) 1:2 as the eluent to afford the title compound as yellow foam.

Workup

  1. customThe crude product was purified by flash chromatography

Sources & evidence

ORD record
ord-97e48b4df8b143f3bfd801b2c46b8a52
Source dataset
uspto-grants-2012_10
Patent number
US08293772B2

Reaction notes

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