HCID 68420710, compound → HCID 86605541, compound

HRID 2067294Notes

Reaction equation

HRID 2067294 reaction equation
[N:1]([C:4]1[CH:5]=[CH:6][C:7]([CH3:30])=[C:8]([C:10]([C:12]2[CH:17]=[CH:16][C:15]([NH:18][C:19]3[CH:24]=[CH:23][C:22](C(F)(F)F)=[CH:21][CH:20]=3)=[CH:14][C:13]=2[Cl:29])=[O:11])[CH:9]=1)=[N+:2]=[N-:3].NC1C=CC(C)=C([C:38](C2C=CC(NC3C=CC=C(OC)C=3)=CC=2Cl)=[O:39])C=1>>[N:1]([C:4]1[CH:5]=[CH:6][C:7]([CH3:30])=[C:8]([C:10]([C:12]2[CH:17]=[CH:16][C:15]([NH:18][C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([O:39][CH3:38])[CH:20]=3)=[CH:14][C:13]=2[Cl:29])=[O:11])[CH:9]=1)=[N+:2]=[N-:3]

Participants

3

Reactant 2

HCID 68420710HCID 68420710, compoundHCID 86605524(5-Azido-2-methyl-phenyl)-[2-chloro-4-(4-trifluoromethyl-phenylamino)-phenyl]-methanone

Product 1

HCID 86605541HCID 86605541, compound

Procedure

The reaction was carried out similarly as described in the preparation of compound 416, using compound 467 (1.77 mmol). The crude product was purified by flash chromatography using EtOAc/petroleum ether (40-60) 1:9 and 1:6 as the eluent to afford the title compound.

Workup

  1. customThe crude product was purified by flash chromatography

Sources & evidence

ORD record
ord-c327cb5729f245e1a9c0c576eafe9ec9
Source dataset
uspto-grants-2012_10
Patent number
US08293772B2

Reaction notes

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