Methyl morpholine oxide → HCID 58031560, compound

Participants

Reaction Steps

To a solution of 2-[3-(4-fluorophenyl)-5-hydroxy-2-oxo-imidazolidin-1-yl]-4-methylthiazole-5-carboxylic acid benzylamide (0.07 g, 0.17 mmol) and tetrapropylammonium perruthenate (0.003 g, 0.008 mmol) in chloroform (15 mL) was added 4-methylmorpholine N-oxide (0.03 g, 0.22 mmol) at ambient temperature. The resulting reaction mixture was stirred at ambient temperature for 1 hour, and filtered through a bed of celite. The filtrate was concentrated in vacuo, and the residue was purified by column chromatography to afford the title compound in 18% yield (0.14 g): mp 217-219° C.; 1H NMR (300 MHz, CDCl3) δ 7.54-7.07 (m, 9H), 6.12 (t, J=5.1 Hz, 1H), 4.55 (d, J=5.1 Hz, 2H), 4.47 (s, 2H), 2.70 (s, 3H); MS (ES+) m/z 425.3 (M+1).

Provenance & Evidence