Ethyl 4-methyl-2-(2-oxo-3-phenylimidazolidin-1-yl)thiazole-5-carboxylate → HCID 58031429, compound

HRID 2067384Notes

Reaction equation

HRID 2067384 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([N:12]2[CH2:16][CH2:15][N:14]([C:17]3C=C[CH:20]=[CH:19][CH:18]=3)[C:13]2=[O:23])[S:5][C:6]=1[C:7]([O:9]CC)=[O:8].C(N1CCN(C2SC(C(OCC)=O)=C(C)N=2)C1=O)CCC>>[CH2:17]([N:14]1[CH2:15][CH2:16][N:12]([C:4]2[S:5][C:6]([C:7]([OH:9])=[O:8])=[C:2]([CH3:1])[N:3]=2)[C:13]1=[O:23])[CH2:18][CH2:19][CH3:20]

Participants

3

Reactant 2

HCID 58031446Ethyl 4-methyl-2-(2-oxo-3-phenylimidazolidin-1-yl)thiazole-5-carboxylateHCID 58031484HCID 58031484, compound

Product 1

HCID 58031429HCID 58031429, compoundYield 94%

Procedure

Following the procedure as described in Example 6, making variations as required to replace ethyl 4-methyl-2-(2-oxo-3-phenylimidazolidin-1-yl)thiazole-5-carboxylate with ethyl 2-(3-butyl-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylate, the title compound was obtained in 94% yield: MS (ES+) m/z 284.2 (M+1).

Sources & evidence

ORD record
ord-e229637e3134454c92af13404626323e
Source dataset
uspto-grants-2012_10
Patent number
US08293768B2

Reaction notes

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