Ethyl 4-methyl-2-(2-oxo-3-phenylimidazolidin-1-yl)thiazole-5-carboxylate → HCID 58031527, compound

HRID 2067385Notes

Reaction equation

HRID 2067385 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([N:12]2[CH2:16][CH2:15][N:14]([C:17]3C=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:13]2=[O:23])[S:5][C:6]=1[C:7]([O:9]CC)=[O:8].CC1N=C(N2CCN(CCCCC)C2=O)SC=1C(OCC)=O>>[CH3:1][C:2]1[N:3]=[C:4]([N:12]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[C:13]2=[O:23])[S:5][C:6]=1[C:7]([OH:9])=[O:8]

Participants

3

Reactant 2

HCID 58031446Ethyl 4-methyl-2-(2-oxo-3-phenylimidazolidin-1-yl)thiazole-5-carboxylateHCID 58031623HCID 58031623, compound

Product 1

HCID 58031527HCID 58031527, compoundYield 65%

Procedure

Following the procedure as described in Example 6, making variations as required to replace ethyl 4-methyl-2-(2-oxo-3-phenylimidazolidin-1-yl)thiazole-5-carboxylate with ethyl 4-methyl-2-(2-oxo-3-pentylimidazolidin-1-yl)thiazole-5-carboxylate, the title compound was obtained in 65% yield: MS (ES+) m/z 298.3 (M+1).

Sources & evidence

ORD record
ord-20d8aa2bd57847ef97515124e19bc78a
Source dataset
uspto-grants-2012_10
Patent number
US08293768B2

Reaction notes

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