Methyl 3-((3-(5-acetyl-4-methylthiazol-2-yl)-2-oxoimidazolidin-1-yl)methyl)benzoate → 3-((3-(5-Acetyl-4-methylthiazol-2-yl)-2-oxoimidazolidin-1-yl)methyl)benzoic acid

HRID 2067390Notes

Reaction equation

HRID 2067390 reaction equation
CC1N=C(N2CCN(C3C=CC=CC=3)C2=O)SC=1C(OCC)=O.[C:24]([C:27]1[S:31][C:30]([N:32]2[CH2:36][CH2:35][N:34]([CH2:37][C:38]3[CH:39]=[C:40]([CH:45]=[CH:46][CH:47]=3)[C:41]([O:43]C)=[O:42])[C:33]2=[O:48])=[N:29][C:28]=1[CH3:49])(=[O:26])[CH3:25]>>[C:24]([C:27]1[S:31][C:30]([N:32]2[CH2:36][CH2:35][N:34]([CH2:37][C:38]3[CH:39]=[C:40]([CH:45]=[CH:46][CH:47]=3)[C:41]([OH:43])=[O:42])[C:33]2=[O:48])=[N:29][C:28]=1[CH3:49])(=[O:26])[CH3:25]

Participants

3

Reactant 2

HCID 58031415Methyl 3-((3-(5-acetyl-4-methylthiazol-2-yl)-2-oxoimidazolidin-1-yl)methyl)benzoateHCID 58031446Ethyl 4-methyl-2-(2-oxo-3-phenylimidazolidin-1-yl)thiazole-5-carboxylate

Product 1

HCID 580316863-((3-(5-Acetyl-4-methylthiazol-2-yl)-2-oxoimidazolidin-1-yl)methyl)benzoic acidYield 89%

Procedure

Following the procedure as described in Example 6, making variations as required to replace ethyl 4-methyl-2-(2-oxo-3-phenylimidazolidin-1-yl)thiazole-5-carboxylate with methyl 3-((3-(5-acetyl-4-methylthiazol-2-yl)-2-oxoimidazolidin-1-yl)methyl)benzoate, the title compound was obtained as a white solid in 89% yield: MS (ES+) m/z 360.1 (M+1).

Sources & evidence

ORD record
ord-066b3d0235454e90b210b0526b5889f6
Source dataset
uspto-grants-2012_10
Patent number
US08293768B2

Reaction notes

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