化工社化工社 化学情報印刷レポート · 研究参考用
1-(Bromomethyl)-4-(trifluoromethyl)benzene → Ethyl 4-methyl-2-(2-oxo-3-(pyridin-2-ylmethyl) imidazolidin-1-yl)thiazole-5-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(Bromomethyl)-4-(trifluoromethyl)benzene | HCID 123062 | — |
| 反応物 | 2-(Bromomethyl)pyridine hydrochloride | HCID 21985098 | — |
| 反応物 | Ethyl 4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxylate | HCID 57919776 | — |
| 生成物 | Ethyl 4-methyl-2-(2-oxo-3-(pyridin-2-ylmethyl) imidazolidin-1-yl)thiazole-5-carboxylate | HCID 58031467 | 55% |
反応手順
Following the procedure as described in Example 13, making variations as required to replace 4-(trifluoromethyl)benzyl bromide with 2-(bromomethyl)pyridine hydrochloride to react with ethyl 4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxylate, the title compound was obtained as a colorless solid in 55% yield: MS (ES+) m/z 347.2 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08293768B2 |
| 出典データセット | uspto-grants-2012_10 |
| ORD ID | ord-2871ac3104dd4a05ae148ab317692a90 |
| 出典メモ | uspto-grants-2012_10 |