1-(Bromomethyl)-4-(trifluoromethyl)benzene → ethyl 4-methyl-2-(5-oxo-1-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-1,2,4-triazol-4(5H)-yl)thiazole-5-carboxylate

Participants

Reaction Steps

Following the procedure as described in Example 19, making variation as required to replace 4-(trifluoromethyl)benzyl bromide with 2-(bromomethyl)-5-(trifluoromethyl)furan to react with ethyl 4-methyl-2-(5-oxo-1H-1,2,4-triazol-4(5H)-yl)thiazole-5-carboxylate, the title compound was obtained as a white solid in 56% yield: 1H NMR (300 MHz, CDCl3) δ 8.26 (s, 1H), 6.69-6.62 (m, 1H), 6.29-6.20 (m, 1H), 5.03 (s, 2H), 4.32 (q, J=7.0 Hz, 2H), 2.64 (s, 3H), 1.35 (t, J=7.0 Hz, 3H); MS (ES+) m/z 403.3 (M+1).

Provenance & Evidence