Ethyl 3-((3-(5-(benzylcarbamoyl)-4-methylthiazol-2-yl)-2-oxoimidazolidin-1-yl)methyl)benzoate → 2-(3-(4-Fluorobenzyl)-2-oxoimidazolidin-1-yl)-4-(trifluoromethyl)thiazole-5-carboxylic acid

Participants

Reaction Steps

Following the procedure as described in Example 25, making variations as required to replace ethyl 3-((3-(5-(benzylcarbamoyl)-4-methylthiazol-2-yl)-2-oxoimidazolidin-1-yl)methyl)benzoate with ethyl 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-4-(trifluoromethyl)thiazole-5-carboxylate, the title compound was obtained as a colorless solid in 69% yield: 1H NMR (300 MHz, DMSO-d6) δ 13.74 (br s, 1H), 7.36-7.30 (m, 2H), 7.19-7.13 (m, 2H), 4.41 (s, 2H), 4.02-3.97 (m, 2H), 3.47-3.41 (m, 2H); MS (ES+) m/z 390.1 (M+1).

Provenance & Evidence