HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(5-(piperidin-1-yl)pentyloxy)-2H-chromen-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 8-(5-Bromopentyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one | HCID 24849569 | — |
| Product | 4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(5-(piperidin-1-yl)pentyloxy)-2H-chromen-2-one | HCID 24849760 | — |
Reaction Steps
The title compound was prepared from piperidine and 8-(5-bromopentyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one (Example 28) following the procedure outlined in Example 52. 1H NMR (400 MHz, DMSO-d6): δ 9.31 (br s, 1H), 8.55 (s, 2H), 7.85 (d, 1H), 7.04 (d, 1H), 4.20 (br s, 1H), 3.96 (t, 2H), 3.87 (s, 3H), 2.90-2.30 (br, 6H), 1.75-1.35 (m, 12H); MS (ESI): 505.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745646B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-0d2f674480da44f68e362539eb2fb3ec |
| Source note | uspto-grants-2010_06 |