Oxazol-2-ylmethanamine → HCID 59481258, compound

Participants

Reaction Steps

Following the procedure as described in Example 32, making variations as required to replace 2-(3-((5-chlorobenzo[b]thiophen-3-yl)methyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acid with 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acid to react with oxazol-2-ylmethanamine, the title compound was obtained as a colorless solid in 32% yield: mp 187-189° C.; 1H NMR (300 MHz, CDCl3) δ 7.65 (s, 1H), 7.30-7.27 (m, 2H), 7.09-7.02 (m, 3H), 6.35 (br s, 1H), 4.70 (d, J=3.0 Hz, 2H), 4.47 (s, 2H), 4.10 (t, J=9.0 Hz, 2H), 3.46 (t, J=9.0 Hz, 2H), 2.64 (s, 3H); MS (ES+) m/z 416.2 (M+1).

Provenance & Evidence