Hydrazine hydrate (1:1) → HCID 58031599, compound

Participants

Reaction Steps

Following the procedure as described in Example 38, making variations as required to replace hydrazine monohydrate with hydroxylamine hydrochloride to react with (E)-1-(5-(3-(dimethylamino)acryloyl)-4-methylthiazol-2-yl)-3-(4-(trifluoromethyl)benzyl)imidazolidin-2-one, the title compound was obtained as a colorless solid in 76% yield: mp 153-154° C. (ethyl acetate/hexanes); 1H NMR (300 MHz, CDCl3) δ 8.23 (d, J=1.8 Hz, 1H), 7.67 (d, J=8.1 Hz, 2H), 7.43 (d, J=8.1 Hz, 2H), 6.23 (d, J=1.8 Hz, 1H), 4.53 (s, 2H), 4.17-4.04 (m, 2H), 3.54-3.41 (m, 2H), 2.53 (s, 3H); 13C NMR (75 MHz, CDCl3) δ 163.2, 158.4, 155.5, 150.5, 148.1, 139.7, 128.5, 125.9, 125.8, 122.1, 111.8, 99.4, 47.6, 42.1, 41.9, 17.1; MS (ES+) m/z 409.1 (M+1).

Provenance & Evidence