Potassium Carbonate → HCID 59317814, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-bromoindole (10 g), potassium carbonate (27 g), copper (I) bromide (0.73 g) and iodobenzene (135 g) was heated to 100° C., then was removed once from the oil bath, sodium hydroxide (1.58 g) and copper (II) acetate (50 mg) were added and the mixture was stirred at 140° C. for 9 hours. From the reaction solution, the insolubles were filtered off, the filtrate was distilled off in vacuo, and the residue obtained was purified by silica gel column chromatography (hexane:ethyl acetate=19:1 to 3:2) to afford the above-identified compound (4.6 g).

Provenance & Evidence