HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N-(4-Bromo-2,6-dimethyl-phenyl)-3,3-dimethyl-butanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3,3-Dimethylbutanoyl chloride | HCID 81514 | — |
| Reactant | 4-Bromo-2,6-xylidine | HCID 90549 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-(4-Bromo-2,6-dimethyl-phenyl)-3,3-dimethyl-butanamide | HCID 59741059 | 100.1% |
Reaction Steps
3,3-Dimethylbutanoyl chloride (3.37 g, 3.5 mL, 25 mmol) and triethylamine (2.53 g, 3.5 mL, 25 mmol) were added to a solution of 4-bromo-2,6-dimethyl-phenylamine (5.0 g, 25 mmol) in acetonitrile (30 mL). The reaction mixture was stirred at room temperature for 4 hours. Water was added to the mixture, and the precipitate which formed was collected to give the title compound as a powder (7.46 g, 100% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293911B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-ac3bf29e954340eb90f36aa6ccf45427 |
| Source note | uspto-grants-2012_10 |