HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N-(4-bromo-2-chloro-6-methylphenyl)-3,3-dimethylbutanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3,3-Dimethylbutanoyl chloride | HCID 81514 | — |
| Reactant | 4-Bromo-2-chloro-6-methylaniline | HCID 2769626 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-(4-bromo-2-chloro-6-methylphenyl)-3,3-dimethylbutanamide | HCID 58097339 | 100% |
Reaction Steps
3,3-Dimethylbutanoyl chloride (3.37 g, 3.5 mL, 25 mmol) and triethylamine (2.53 g, 3.5 mL, 25 mmol) were added to a solution of 4-Bromo-2-chloro-6-methyl-phenylamine (5.0 g, 25 mmol) in acetonitrile (30 mL). The reaction mixture was stirred at room temperature for 4 hours. Water was added to the mixture and the precipitate formed collected to give the title compound as a powder (7.46 g, 100% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293911B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-850cc275585042c8871b909526572bb7 |
| Source note | uspto-grants-2012_10 |