Water → HCID 17311837, compound

HRID 2067818Notes

Reaction equation

HRID 2067818 reaction equation
[CH3:1][C:2]([CH3:8])([CH3:7])[CH2:3][C:4](Cl)=[O:5].[Br:9][C:10]1[CH:15]=[CH:14][C:13]([NH2:16])=[C:12]([Cl:17])[CH:11]=1.O>C(#N)C>[Br:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:4](=[O:5])[CH2:3][C:2]([CH3:8])([CH3:7])[CH3:1])=[C:12]([Cl:17])[CH:11]=1

Participants

5

Reactant 3

HCID 962WaterHCID 815143,3-Dimethylbutanoyl chlorideHCID 6101694-Bromo-2-chloroaniline

Product 1

HCID 17311837HCID 17311837, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

3,3-Dimethylbutanoyl chloride (717 mg, 0.74 mL, 5.32 mmol) was added to a solution of 4-Bromo-2-chloro-phenylamine (1.0 g, 4.84 mmol) in acetonitrile (10 mL). The reaction mixture was stirred at room temperature overnight. Water was added to the mixture and the precipitate formed collected to give the title compound as a powder (1.04 g, 72% yield).

Workup

  1. customthe precipitate formed
  2. customcollected

Sources & evidence

ORD record
ord-79c86d3d47134f3da4a9b58cc2a292a4
Source dataset
uspto-grants-2012_10
Patent number
US08293911B2

Reaction notes

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