Water → HCID 58097333, compound

HRID 2067819Notes

Reaction equation

HRID 2067819 reaction equation
[CH3:1][C:2]([CH3:8])([CH3:7])[CH2:3][C:4](Cl)=[O:5].[Br:9][C:10]1[CH:15]=[CH:14][C:13]([NH2:16])=[C:12]([C:17]([F:20])([F:19])[F:18])[CH:11]=1.O>C(#N)C>[Br:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:4](=[O:5])[CH2:3][C:2]([CH3:8])([CH3:7])[CH3:1])=[C:12]([C:17]([F:18])([F:19])[F:20])[CH:11]=1

Participants

5

Reactant 3

HCID 962WaterHCID 679604-Bromo-2-(trifluoromethyl)anilineHCID 815143,3-Dimethylbutanoyl chloride

Product 1

HCID 58097333HCID 58097333, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

3,3-Dimethylbutanoyl chloride (617 mg, 0.64 mL, 4.6 mmol) was added to a solution of 4-Bromo-2-trifluoromethyl-phenylamine (1.0 g, 4.16 mmol) in acetonitrile (10 mL). The reaction mixture was stirred at room temperature overnight. Water was added to the mixture and the precipitate formed collected to give the title compound as a powder (1.1 g, 79% yield).

Workup

  1. customthe precipitate formed
  2. customcollected

Sources & evidence

ORD record
ord-3603b4516532412dbd7e1b5f7b5d35f5
Source dataset
uspto-grants-2012_10
Patent number
US08293911B2

Reaction notes

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