2-(4-Nitrophenoxy)ethanol → 2-(4-Aminophenoxy)ethanol

Participants

Reaction Steps

2-(4-Nitrophenoxy)ethanol 8 (109 mmol) and Pd/C (10% wt.) are suspended in EtOH (50 mL) and allowed to absorb 30 psi of hydrogen in a Parr shaker. The mixture is shaken at rt for 16 h. After filtration and concentration, 2-(4-aminophenoxy)ethanol 9 is obtained as a light pink colored solid and used in the next step without purification. MS (m/z) (M+1)+: 154.1.

Provenance & Evidence