HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2067871Generated: November 1, 2026
Sodium Carbonate → Methyl 1-(4-(5-bromopyrimidin-2-ylamino)phenethyl)piperidine-4-carboxylate
https://huagongshe.com/reaction/2067871
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Methyl isonipecotate | HCID 424914 | — |
| Reactant | 4-(5-Bromopyrimidin-2-ylamino)phenethyl methanesulfonate | HCID 86660117 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 1-(4-(5-bromopyrimidin-2-ylamino)phenethyl)piperidine-4-carboxylate | HCID 68727496 | — |
Reaction Steps
The reaction mixture of 4-(5-bromopyrimidin-2-ylamino)phenethyl methanesulfonate 19 (1.55 mmol) and methyl isonipecotate (3.10 mmol) in DMF (5 mL) is stirred at 90° C. for 12 h. After the reaction is complete, Na2CO3 (2.0 M, 20 mL) is added and the resulting mixture is extracted with EtOAc (50 mL). The organic layer is separated and concentrated to give crude methyl 1-(4-(5-bromopyrimidin-2-ylamino)phenethyl)piperidine-4-carboxylate 20. MS (m/z) (M+1)+: 419.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08293757B2 |
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| Source dataset | uspto-grants-2012_10 |
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| ORD ID | ord-f1f3a2ad8ea641c3b91a9144dbcd469b |
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| Source note | uspto-grants-2012_10 |
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