Sodium borohydride → (6-Chloropyridazin-3-yl)methanol

HRID 2067916Notes

Reaction equation

HRID 2067916 reaction equation
[Cl:1][C:2]1[N:7]=[N:6][C:5]([CH:8]=[O:9])=[CH:4][CH:3]=1.[BH4-].[Na+]>CO>[Cl:1][C:2]1[N:7]=[N:6][C:5]([CH2:8][OH:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 223362676-Chloropyridazine-3-carbaldehyde

Product 1

HCID 20557609(6-Chloropyridazin-3-yl)methanol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 6-chloropyridazine-3-carbaldehyde (2.50 g, 17.5 mmol) in 30 mL of methanol (30 mL) at 0° C. was added sodium borohydride (0.26 g, 7.02 mmol). The reaction mixture was warmed to room temperature. After 2 hours, the reaction mixture was concentrated in vacuo and triturated with 20% MeOH in dichloromethane to provide (6-chloropyridazin-3-yl)methanol.

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo
  2. customtriturated with 20% MeOH in dichloromethane

Sources & evidence

ORD record
ord-d75aebc425c6462592b75a9d4a61eee8
Source dataset
uspto-grants-2012_10
Patent number
US08293914B2

Reaction notes

Loading…