HCID 86602962, compound → HCID 86602963, compound

HRID 2067928Notes

Reaction equation

HRID 2067928 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:13]([CH3:14])=[C:12]([CH2:15][OH:16])[N:11]=[C:10]1[CH3:17]>ClCCl>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:13]([CH3:14])=[C:12]([CH:15]=[O:16])[N:11]=[C:10]1[CH3:17]

Participants

3

Reactant 1

HCID 86602962HCID 86602962, compound

Product 1

HCID 86602963HCID 86602963, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

[1-(2,4-Difluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-yl]-methanol (0.38 g, 1.6 mmol) was dissolved in 35 ml dichloromethane. Mangan(IV)oxid (1.38 g, 16 mmol) was added, and the reaction mixture stirred at reflux for 2 hrs. The suspension was filtered through a dicalite speed plus pad and washed with dichloromethane. The solvents were evaporated, and the desired compound was obtained as a yellow oil (0.325 g, 86%), MS: m/e=237.1 (M+H+).

Workup

  1. temperatureat reflux for 2 hrs
  2. filtrationThe suspension was filtered through a dicalite speed plus pad
  3. washwashed with dichloromethane
  4. customThe solvents were evaporated

Sources & evidence

ORD record
ord-dbd2313e26a5495a82c2d894f770ef94
Source dataset
uspto-grants-2012_10
Patent number
US08293916B2

Reaction notes

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