反应详情

[1-(2,4-Difluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-yl]-methanol (0.38 g, 1.6 mmol) was dissolved in 35 ml dichloromethane. Mangan(IV)oxid (1.38 g, 16 mmol) was added, and the reaction mixture stirred at reflux for 2 hrs. The suspension was filtered through a dicalite speed plus pad and washed with dichloromethane. The solvents were evaporated, and the desired compound was obtained as a yellow oil (0.325 g, 86%), MS: m/e=237.1 (M+H+).

1. temperatureat reflux for 2 hrs
2. filtrationThe suspension was filtered through a dicalite speed plus pad
3. washwashed with dichloromethane
4. customThe solvents were evaporated