4-Fluoroiodobenzene → HCID 68707181, compound

HRID 2067935Notes

Reaction equation

HRID 2067935 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5](I)=[CH:4][CH:3]=1.[CH2:9]([O:11][C:12]([Sn](CCCC)(CCCC)CCCC)=[CH2:13])[CH3:10]>C1(C)C=CC=CC=1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH2:12]([O:11][C:9]([C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)=[CH2:10])[CH3:13]

Participants

5

Reactant 2

HCID 96054-FluoroiodobenzeneHCID 619414Stannane, tributyl(1-ethoxyethenyl)-

Product 1

HCID 68707181HCID 68707181, compound

Reagents, catalysts & solvents 2

HCID 178418397HCID 178418397, compoundCatalystHCID 1140TolueneSolvent

Procedure

A solution of 10.0 g 4-Fluoro-iodobenzene, 21.1 g 1-Ethoxyvinyltributyltin and 2.6 g Tetrakis(triphenylphosphine)Palladium in 130 ml of Toluene was refluxed overnight under an argon atmosphere. The dark brown solution was filtered over filter aid and concentrated in vaccuo. The crude dark brown oil (7.49 g) was directly used in the next step.

Workup

  1. filtrationThe dark brown solution was filtered
  2. filtrationover filter aid
  3. concentrationconcentrated in vaccuo

Sources & evidence

ORD record
ord-b43381387ea943df96f504fb1b7ce157
Source dataset
uspto-grants-2012_10
Patent number
US08293916B2

Reaction notes

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