HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → (Z)-2-Acetylamino-3-dimethylamino-but-2-enoic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (Z)-4-(1-(Dimethylamino)ethylidene)-2-methyloxazol-5(4H)-one | HCID 67495069 | — |
| Product | (Z)-2-Acetylamino-3-dimethylamino-but-2-enoic acid ethyl ester | HCID 86595898 | — |
Reaction Steps
4-[1-Dimethylamino-eth-(Z)-ylidene]-2-methyl-4H-oxazol-5-one (7.4 g, 44.0 mmol) was dissolved in ethanol (50 ml), and sodium hydride (0.10 g, 4.4 mmol) was added at room temperature. The dark solution was refluxed for 1 h. The solvent was evaporated, and the crude product [MS: m/e=215.5 (M+H+)] was used without any further purification for the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293916B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-81f953fea32e40dc8344c7bdb61e680a |
| Source note | uspto-grants-2012_10 |