Lithium Hydroxide → HCID 15655153, compound

Participants

Reaction Steps

To a solution of 1-(4-chloro-phenyl)-5-methoxymethyl-1H-pyrazole-4-carboxylic acid methyl ester (6.0 g, 21 mmol) in H2O-MeOH-THF (1:1:2) is added lithium hydroxide (620 mg, 26 mmol). After stiffing at room temperature for 18 h, the reaction mixture is concentrated in vacuo and purified by flash chromatography on silica gel (eluted with 15 to 100% EtOAc/hexanes) to afford 1-(4-chloro-phenyl)-5-methoxymethyl-1H-pyrazole-4-carboxylic acid as a white solid (3.8 g, 66%).

Provenance & Evidence