Hydrochloric Acid → HCID 58443379, compound

Participants

Reaction Steps

3-(3-Bromo-phenyl)-3-{[1-(3,4-dichloro-phenyl)-5-methyl-1H-pyrazole-4-carbonyl]-amino}-propionic acid methyl ester (1.5 g, 2.9 mmol) is treated with aqueous NaOH (1.0 N solution, 60 mL, 60 mmol) and stirred at reflux for 1 hour. After cooling to room temperature, the reaction mixture is acidified with aqueous 1N HCl. The resultant precipitate is collected by filtration and dried in vacuo to afford 3-(3-bromo-phenyl)-3-{[1-(3,4-dichloro-phenyl)-5-methyl-1H-pyrazole-4-carbonyl]-amino}-propionic acid as a off-white solid (870 mg, 60%).

Provenance & Evidence