Thionyl Chloride → HCID 58443402, compound

Participants

Reaction Steps

A solution of 3-(3-bromo-phenyl)-3-{[1-(3,4-dichloro-phenyl)-5-methyl-1H-pyrazole-4-carbonyl]-amino}-propionic acid (870 mg, 1.8 mmol) in thionyl chloride (40 mL) is heated at reflux for 1 hour. After cooling to room temperature, the reaction mixture is concentrated in vacuo to afford 3-(3-bromo-phenyl)-3-{[1-(3,4-dichloro-phenyl)-5-methyl-1H-pyrazole-4-carbonyl]-amino}-propionyl chloride as an off-white solid (880 mg, 98%) which is used without further purification.

Provenance & Evidence