Ammonia → HCID 44480346, compound

Participants

Reaction Steps

5-Bromomethyl-1-(4-chloro-phenyl)-1H-pyrazole-4-carboxylic acid [(S)-1-(3-trifluoromethyl-phenyl)-butyl]-amide (47 mg, 0.091 mmol) is treated with ammonia in methanol (7.0 N solution, 2.0 mL, 14 mmol) and the resultant solution is heated in a microwave at 120° C. for 3 min. The crude reaction mixture is concentrated in vacuo and purified by preparative reverse phase HPLC (eluted with 10 to 90% CH3CN/H2O and 0.1% TFA as additive) to afford 5-aminomethyl-1-(4-chloro-phenyl)-1H-pyrazole-4-carboxylic acid [(S)-1-(3-trifluoromethyl-phenyl)-butyl]-amide (25 mg, 61%).

Provenance & Evidence